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The metal tolerance protein OsMTP11 facilitates cadmium sequestration in the vacuoles of leaf vascular cells for restricting its translocation into rice grains

文献类型： 外文期刊

作者： Liu, Peng 1 ; Sun, Liang 1 ; Zhang, Yu 1 ; Tan, Yongjun 1 ; Zhu, Yuxing 1 ; Peng, Can 1 ; Wang, Jiurong 1 ; Yan, Huili 3 ; Mao, Donghai 1 ; Liang, Guohua 4 ; Liang, Gang 5 ; Li, Xiaoxiang 6 ; Liang, Yuntao 7 ; Wang, Feng 2 ; He, Zhenyan 3 ; Tang, Wenbang 2 ; Huang, Daoyou 1 ; Chen, Caiyan 1 ;

作者机构： 1.Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr, Changsha 410125, Peoples R China

2.Hunan Agr Univ, Coll Agron, Changsha 410128, Peoples R China

3.Chinese Acad Sci, Key Lab Plant Resources, Inst Bot, Beijing 100093, Peoples R China

4.Yangzhou Univ, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou 225009, Peoples R China

5.Chinese Acad Sci, CAS Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Kunming 650223, Yunnan, Peoples R China

6.Hunan Acad Agr Sci, Hunan Rice Res Inst, Changsha 410125, Peoples R China

7.Guangxi Acad Agr Sci, Rice Res Inst, Guangxi Key Lab Rice Genet & Breeding, Nanning 530007, Peoples R China

8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

关键词： rice; OsCS1/OsMTP11; grain Cd; TGN-PVC-vacuole transport; allelic variation

期刊名称：MOLECULAR PLANT （ 影响因子：24.1； 五年影响因子：25.8 ）

ISSN： 1674-2052

年卷期： 2024 年 17 卷 11 期

页码：

收录情况： SCI

摘要： Rice (Oryza sativa) provides >20% of the consumed calories in the human diet. However, rice is also a leading source of dietary cadmium (Cd) that seriously threatens human health. Deciphering the genetic network that underlies the grain-Cd accumulation will benefit the development of low-Cd rice and mitigate the effects of Cd accumulation in the rice grain. In this study, we identified a QTL gene, OsCS1, which is allelic to OsMTP11 and encodes a protein sequestering Cd in the leaf during vegetative growth and preventing Cd from being translocated to the grain after heading in rice. OsCS1 is predominantly expressed in leaf vascular parenchyma cells, where it binds to a vacuole-sorting receptor protein OsVSR2 and is translocated intracellularly from the trans-Golgi network to pre-vacuolar compartments and then to the vacuole. In this trafficking process, OsCS1 actively transports Cd into the endomembrane system and sequesters it in the vacuoles. There are natural variations in the promoter of OsCS1 between the indica and japonica rice subspecies. Duplication of a G-box-like motif in the promoter region of the superior allele of OsCS1 from indica rice enhances the binding of the transcription factor OsIRO2 to the OsCS1 promoter, thereby promoting OsCS1 expression. Introgression of this allele into commercial rice varieties could significantly lower grain-Cd levels compared to the inferior allele present in japonica rice. Collectively, our findings offer new insights into the genetic control of leaf-to-grain Cd translocation and provide a novel gene and its superior allele for the genetic improvement of low-Cd variety in rice.

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