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Discovery of N-Benzyl-4-(1-bromonaphthalen-2-yl)oxybutan-1-amine as a Potential Antifungal Agent against Sporidia Growth and Teliospore Germination of Sporisorium scitamineum

文献类型： 外文期刊

作者： Cai, Enping 1 ; Zeng, Rong 1 ; Feng, Ruqing 1 ; Zhang, Li 1 ; Li, Lei 1 ; Jia, Huan 1 ; Zheng, Wenqiang 1 ; Chen, Shaofang 1 ; Yan, Meixin 3 ; Chang, Changqing 1 ;

作者机构： 1.South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobio, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China

2.South China Agr Univ, Coll Plant Protect, Integrate Microbiol Res Ctr, Guangdong Prov Key Lab Microbial Signals & Dis Con, Guangzhou 510642, Peoples R China

3.Guangxi Acad Agr Sci, Sugarcane Res Inst, Nanning 530000, Peoples R China

关键词： Sporisorium scitamineum; heat shock protein 104; MAP kinase Hog1; N-benzyl-4-(1-bromonaphthalen-2-yl)oxybutan-1-amine

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 7 期

页码：

收录情况： SCI

摘要： The cultivation of sugar cane using perennial roots is the primary planting method, which is one of the reasons for the serious occurrence of sugar cane smut disease caused by the basidiomycetous fungus Sporisorium scitamineum in the sugar cane perennial root planting area. Consequently, it is crucial to eliminate pathogens from perennial sugar cane buds. In this study, we found that MAP kinase Hog1 is necessary for heat stress resistance. Subsequent investigations revealed a significant reduction in the expression of the heat shock protein 104-encoding gene, SsHSP104, in the ss1hog1 Delta mutant. Additionally, the overexpression of SsHSP104 partially restored colony growth in the ss1hog1 Delta strain following heat stress treatment, demonstrating the crucial role of SsHsp104 in SsHog1-mediated heat stress tolerance. Hence, we constructed the ss1hsp104:eGFP fusion strain in the wild type of S. scitamineum to identify small-molecule compounds that could inhibit the heat stress response, leading to the discovery of N-benzyl-4-(1-bromonaphthalen-2-yl)oxybutan-1-amine as a potential compound that targets the SsHog1 mediation SsHsp104 pathway during heat treatment. Furthermore, the combination of N-benzyl-4-(1-bromonaphthalen-2-yl)oxybutan-1-amine and warm water treatment (45 degrees C for 15 min) inhibits the growth of S. scitamineum and teliospore germination, thereby reducing the occurrence of sugar cane smut diseases and indicating its potential for eliminating pathogens from perennial sugar cane buds. In conclusion, these findings suggest that N-benzyl-4-(1-bromonaphthalen-2-yl)oxybutan-1-amine is promising as a targeted compound for the SsHog1-mediated SsHsp104 pathway and may enable the reduction of hot water treatment duration and/or temperature, thereby limiting the occurrence of sugar cane smut diseases caused by S. scitamineum.

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