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Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation

文献类型： 外文期刊

作者： Shen, Yingbin 2 ; Song, Xun 1 ; Li, Li 3 ; Sun, Jian 3 ; Jaiswal, Yogini 9 ; Huang, Junqing 5 ; Liu, Chun 7 ; Yang, Wenji 1 ;

作者机构： 1.Univ Minnesota, Coll Pharm, Ctr Drug Design, Minneapolis, MN 55455 USA

2.Jinan Univ, Sch Sci & Engn, Dept Food Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China

3.Guangxi Acad Agr Sci, Agrofood Sci & Technol Res Inst, Nanning 530007, Guangxi, Peoples R China

4.Guangxi Key Lab Fruits & Vegetables Storage Proc, Nanning 530007, Guangxi, Peoples R China

5.Jinan Univ, Formula Pattern Res Ctr, Sch Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China

6.Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

7.Ctr South Univ Forestry & Technol, Natl Engn Lab Rice & Byprod Deep Proc, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China

8.Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Nanjing 210023, Jiangsu, Peoples R China

9.North Carolina A&

关键词： p-Courmaric acid; Antioxidant activity; Oxidative stress; PC12 cells; High fat-diet mice model

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：6.529； 五年影响因子：5.979 ）

ISSN： 0753-3322

年卷期： 2019 年 111 卷

页码：

收录情况： SCI

摘要： Dietary phenols are antioxidants with diverse physiological functions that are beneficial for human health. The objective of this research work was to investigate antioxidant activity of p-coumaric acid (p-CA) using four in vitro methods, the protective effects against oxidative stress in PC12 cells, and hypolipidemic effects on High fat-diet (HFD) mice model. The p-CA exhibited moderate antioxidant activity in the selected in vitro assay. The highest chelating activity of p-CA at 50 mu g/mL was found to be 52.22%. Pretreatment with p-CA significantly enhanced cell viability of PC12 cell and suppressed AAPH-induced intracellular ROS generation and AAPH-induced LDH release. The hypolipidemic effects of p-CA (100 mg/kg BW) was directly linked to the increased expression of nuclear factor erythroid 2-related factor (Nrf2) by 2.0-fold, Glutathione peroxidase (Gpx) by 3.8-fold, Superoxide dismutase (SOD-1) by 1.6-fold, Heme oxygenase (HO-1) by 1.72-fold and NAD(P)H Quinone Dehydrogenase 1 (NQO-1) by 1.5-fold compared with HFD group. In addition to these effects, p-CA decreased total cholesterol and atherosclerosis index levels, and increased catalase (CAT) level in serum, total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) levels in liver as compared HFD group. Administration of p-CA also promoted the recovery of hyperlipidemia steatohepatitis in mice by ameliorating lipid peroxidation. These results suggested that p-CA is a potent antioxidant with potential therapeutic efficacy for treating hyperlipidemia symptoms.

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