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Soy husk extract improves physical and biochemical parameters of obese-diabetic rats through the regulation of PPAR expression

文献类型： 外文期刊

作者： Tan, Seok-Tyug 2 ; Ismail, Amin 1 ; Hamid, Muhajir 4 ; Chong, Pei-Pei 6 ; Sun, Jian 7 ;

作者机构： 1.Univ Putra Malaysia, Dept Nutr & Dietet, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia

2.Management & Sci Univ, Fac Hlth & Life Sci, Dept Healthcare Profess, Shah Alam, Malaysia

3.Univ Putra Malaysia, Halal Prod Res Inst, Serdang, Malaysia

4.Univ Putra Malaysia, Dept Microbiol, Fac Biotechnol & Biomol Sci, Serdang, Malaysia

5.Univ Putra Malaysia, Inst Biosci, Serdang, Malaysia

6.Taylors Univ, Sch Biosci, Fac Hlth & Med Sci, Lakeside Campus, Subang Jaya, Malaysia

7.Guangxi Acad Agr Sci, Inst Agrofood Sci & Technol, Nanning, Peoples R China

关键词： obese-diabetes; phenolics; PPAR; soy husk

期刊名称：JOURNAL OF FOOD BIOCHEMISTRY （ 影响因子：2.72； 五年影响因子：2.543 ）

ISSN： 0145-8884

年卷期： 2019 年 43 卷 5 期

页码：

收录情况： SCI

摘要： Unhealthy eating habits and lack of physical activities are among the contributing factors for obesity and diabetes. It has been reported that consumption of naturally occurring phenolics could exert beneficial effects toward these diseases. Therefore, this study aims to evaluate the ability of phenolic-rich soy husk powder extract (SHPE) in modifying the physical and biochemical parameters for obesity and diabetes. Forty-nine Sprague Dawley rats were divided into seven groups, including three supplementary/treatment groups. Rats in supplementary/treatment groups were provided with either 4mg/kg BW Rosiglitazone Maleate, 250mg SHPE/kg BW, or 500mg SHPE/kg BW. The effectiveness of SHPE in alleviating obesity-diabetes was evaluated by measuring body weight (physical parameter), blood glucose metabolisms (biochemical parameters), and PPAR expression. Findings in the present study revealed that short-term SHPE and Rosiglitazone Maleate administration improved the physical and biochemical parameters of obese-diabetic rats. In addition, SHPE was also demonstrated to upregulate PPAR expression in adipocytes. These findings suggest that soy husk could emerge as a potential hypoglycemic and anti-adipogenic nutraceutical in future. Practical applicationsThis was the first study to evaluate the potential effects of soy husk against the parameters of obese-diabetes in rats. In addition, promising effects derived from this study might explore the possibility of soy husk to be utilized as an antidiabetes nutraceutical.

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