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Discussion on the Structural Modification and Anti-tumor Activity of Flavonoids

文献类型： 外文期刊

作者： Zhou, Zhu-Gui 1 ; Li, Dong-Dong 2 ; Chen, Ying 3 ; Chen, Xi 1 ; Man, Ruo-Jun 4 ;

作者机构： 1.Guangxi Acad Agr Sci, Agrofood Sci & Technol Res Inst, Guangxi Key Lab Fruits & Vegetables Storage Proc, Nanning 530007, Peoples R China

2.Nanjing Forestry Univ, Coll Chem Engn, 159 Long Pan Rd, Nanjing 210037, Peoples R China

3.Guangxi Univ Nationalities, Nanning 530006, Peoples R China

4.Guangxi Minzu Univ, Coll Chem & Chem Engn, Guangxi Key Lab Polysaccharide Mat & Modificat, Nanning 530006, Peoples R China

关键词： Flavonoids; Structural modification; Drug design; Anti-tumor activity; Mechanisms; Apoptosis

期刊名称：CURRENT TOPICS IN MEDICINAL CHEMISTRY （ 影响因子：3.57； 五年影响因子：4.255 ）

ISSN： 1568-0266

年卷期： 2022 年 22 卷 7 期

页码：

收录情况： SCI

摘要： Flavonoids are secondary metabolites of plants. In general,most flavonoids are combined with glucosides and have extremely complex molecular structures. In nature, these flavonoids have a variety of biological activities, such as anti-oxidation,anti-virus, anti-tumor, scavenging free radicals, etc.; however,due to poor solubility and stability of flavonoids,their bioavailability is limited. The drug design method is used to modify the structure of flavonoids to give them special properties. At present, flavonoids have shown broad application prospects in treating tumors, inhibiting proliferation, migration, invasion, angiogenesis, and multi-drug resistance of tumors and have become a research hotspot.

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