Mechanistic Insights into the Antioxidant Potential of Sugarcane Vinegar Polyphenols: A Combined Approach of DPPH-UPLC-MS, Network Pharmacology and Molecular Docking
文献类型： 外文期刊
作者： Wu, Feifei 1 ; Lin, Bo 2 ; Chen, Jing 1 ; Zheng, Fengjin 2 ; Yang, Yuxia 2 ; Rasheed, Usman 3 ; Chen, Ganlin 3 ;
作者机构： 1.Guangxi Acad Agr Sci, Guangxi South Subtrop Agr Sci Res Inst, Longzhou 532400, Peoples R China
2.Guangxi Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Nanning 530007, Peoples R China
3.Guangxi Acad Agr Sci, Guangxi Subtrop Crops Res Inst, Nanning 530001, Peoples R China
4.Minist Agr & Rural Affairs, Key Lab Qual & Safety Control Subtrop Fruit & Vege, Nanning 530001, Peoples R China
5.Guangxi Key Lab Qual & Safety Control Subtrop Frui, Nanning 530001, Peoples R China
关键词： sugarcane vinegar polyphenols; antioxidants; oxidative stress; DPPH-UPLC-MS; network pharmacology; molecular docking
期刊名称：FOODS （ 影响因子：5.1； 五年影响因子：5.6 ）
ISSN：
年卷期： 2024 年 13 卷 21 期
页码：
收录情况： SCI
摘要： This study investigated the antioxidant potential of sugarcane vinegar, an emerging functional food, by analyzing its polyphenols and underlying molecular mechanisms that intervene in oxidative stress. Using a 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) assay combined with UPLC-MS analysis, six key polyphenols were identified: chlorogenic acid, caffeic acid, ferulic acid, luteolin, protocatechuic acid, and syringic acid. These compounds showed a positive correlation with antioxidant capacity. In a simulated sugarcane vinegar environment, these polyphenols exhibited synergistic antioxidant effects, while in methanol, antagonistic interactions were predominant. Network pharmacology revealed five key polyphenols targeting 10 critical proteins involved in oxidative stress, including the PI3K-Akt and IL-17 signaling pathways. Molecular docking confirmed strong binding affinities between these polyphenols and core targets like PTGS2, STAT3, and GSK3B. This study establishes a reference for the antioxidant mechanisms of sugarcane vinegar and highlights its potential for developing functional products.
- 相关文献
作者其他论文 更多>>
-
A Rapid PCR-LAMP Assay for the Early Detection of Lasiodiplodia theobromae from Basal Stem Rot-Infected Passion Fruit Plants
作者：Liu, Ying;Rasheed, Usman;Shan, Bin;Lu, Qinyu;Chen, Shimiao;Meng, Kaikai;Mo, Ganhui;Liu, Ying;Rasheed, Usman;Shan, Bin;Lu, Qinyu;Chen, Shimiao;Meng, Kaikai;Mo, Ganhui;Qin, Aiying
关键词：Passion fruit; Basal stem rot; Loop-mediated isothermal amplification; Hydroxy naphthol blue; Phytopathogen detection;
Lasiodiplodia theobromae -
Metagenomics and transcriptomics analysis of aspartame's impact on gut microbiota and glioblastoma progression in a mouse model
作者：Meng, Kaikai;Chen, Ganlin;Qu, Junru;Meng, Kaikai;Chen, Ganlin;Qu, Junru;Bao, Yi;An, Sanqi;Bao, Yi;An, Sanqi;Bao, Yi;An, Sanqi;Liang, Shuaiyi;Chen, Yang;Liu, Xinli;Fu, Xuanjian
关键词：Aspartame; Metagenomics; RNA; N6-methyladenosine; Glioblastoma
-
Redox-driven sustainable solutions: Metal-polydopamine composites for tetracycline remediation and antifungal applications
作者：Ul Ain, Qurat;Liang, Pingfei;Liu, Kun;Tong, Zhangfa;Ul Ain, Qurat;Huang, Kai;Rasheed, Usman;Rasheed, Usman
关键词：Polydopamine; Tetracycline; Adsorption; Bentonite; Antifungal
-
The regulatory mechanism controlling nitrification inhibitors-induced mitigation of nitrification and NO3--N leaching in alkaline purple soil
作者：Liu, Fabo;Zou, Wenxin;Lang, Ming;Li, Zhao Lei;Zhang, Fen;Wang, Xiaozhong;Chen, Xinping;Liu, Fabo;Lakshmanan, Prakash;Zou, Wenxin;Lang, Ming;Li, Zhao Lei;Zhang, Fen;Wang, Xiaozhong;Chen, Xinping;Lakshmanan, Prakash;Lakshmanan, Prakash;Lang, Ming;Li, Zhao Lei;Wang, Xiaozhong;Chen, Xinping;Lang, Ming;Li, Zhao Lei;Wang, Xiaozhong;Chen, Xinping;Liang, Tao;Chen, Jing;Wang, Yan
关键词：Nitrification inhibitors; Ammonia oxidizers; Vegetable; Purple soil
-
Application of Microbial Fermentation in Caffeine Degradation and Flavor Modulation of Coffee Beans
作者：Ran, Lu-Xia;Wei, Xiang-Ying;Ren, Er-Fang;Qin, Jian-Feng;Rasheed, Usman;Chen, Gan-Lin;Ran, Lu-Xia;Wei, Xiang-Ying;Rasheed, Usman;Chen, Gan-Lin;Ran, Lu-Xia;Wei, Xiang-Ying;Rasheed, Usman;Chen, Gan-Lin
关键词：decaffeination; low-caffeine coffee; microbial fermentation; mixed-culture; flavor enhancement
-
Precise formation of food applied Pickering droplets and microspheres using microfluidic technology
作者：Wei, Xiangying;Yao, Xiaolin;Liu, Wenguang;Mei, Yilin;Yue, Juan;Li, Guoliang;Wei, Xiangying;Chen, Ganlin;Wei, Xiangying;Chen, Ganlin;Wei, Xiangying;Chen, Ganlin;Zhao, Mouming
关键词：Microfluidics; Pickering droplets; Microspheres; Morphology; Interfacial characteristics; Food-grade
-
Response of alcohol fermentation strains, mixed fermentation and extremozymes interactions on wine flavor
作者：Zhao, Ling-Zhi;Zhao, Ling-Zhi;Chen, Jing;Wei, Xiang-Ying;Chen, Gan-Lin;Chen, Jing;Wei, Xiang-Ying;Chen, Gan-Lin;Chen, Jing;Wei, Xiang-Ying;Chen, Gan-Lin;Lin, Bo;Zheng, Feng-Jin;Verma, Krishan K.
关键词：alcohol fermentation; bacteria; extremophiles; single and mixed strain fermentation; strain improvement; wine flavor
