Anti-Obesity Activity of Sanghuangporus vaninii by Inhibiting Inflammation in Mice Fed a High-Fat Diet
文献类型： 外文期刊
作者： Hao, Jie 1 ; Jin, Xinghui 1 ; Li, Zhige 1 ; Zhu, Yanfeng 1 ; Wang, Lu 1 ; Jiang, Xue 2 ; Wang, Di 1 ; Qi, Liangliang 4 ; Jia, Dongxu 1 ; Gao, Bo 1 ;
作者机构： 1.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China
2.Changchun Univ Sci & Technol, Coll Life Sci & Technol, Changchun 130022, Peoples R China
3.Jilin Agr Univ, Chinese Minist Educ Edible & Med Fungi, Engn Res Ctr, Changchun 130118, Peoples R China
4.Guangxi Acad Agr Sci, Microbiol Res Inst, Nanning 530007, Peoples R China
关键词： Sanghuangpours vaninii; obesity; lipids; inflammation; TLR4/NF-kappa B
期刊名称：NUTRIENTS （ 影响因子：4.8； 五年影响因子：5.8 ）
ISSN：
年卷期： 2024 年 16 卷 13 期
页码：
收录情况： SCI
摘要： Obesity is an unhealthy condition associated with various diseases characterized by excess fat accumulation. However, in China, the prevalence of obesity is 14.1%, and it remains challenging to achieve weight loss or resolve this issue through clinical interventions. Sanghuangpours vaninii (SPV) is a nutritional fungus with multiple pharmacological activities and serves as an ideal dietary intervention for combating obesity. In this study, a long-term high-fat diet (HFD) was administered to induce obesity in mice. Different doses of SPV and the positive drug simvastatin (SV) were administered to mice to explore their potential anti-obesity effects. SPV regulated weight, serum lipids, and adipocyte size while inhibiting inflammation and hepatic steatosis. Compared with the vehicle-treated HFD-fed mice, the lowest decreases in total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) were 9.72%, 9.29%, and 12.29%, respectively, and the lowest increase in high-density lipoprotein cholesterol (HDL-C) was 5.88% after treatment with different doses of SPV. With SPV treatment, the analysis of gut microbiota and serum lipids revealed a significant association between lipids and inflammation-related factors, specifically sphingomyelin. Moreover, Western blotting results showed that SPV regulated the toll-like receptor (TLR4)/nuclear factor kappa B (NF-kappa B) signaling pathway in HFD-diet mice, which is related to inflammation and lipid metabolism. This research presents empirical proof of the impact of SPV therapy on obesity conditions.
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