文献类型： 外文期刊

作者： Sun, Dali ¹ ; Wang, Yunru ⁴ ; Zhang, Qinghai ¹ ; Pang, Junxiao ² ;

作者机构： 1.Guizhou Med Univ, Coll Food Safety, Guiyang 550025, Guizhou, Peoples R China

2.Guiyang Univ, Food & Pharmaceut Engn Inst, Key Lab Crit Technol Degradat Pesticide Residues, Guiyang 550005, Guizhou, Peoples R China

3.Guizhou Med Univ, Key Lab Environm Pollut Monitoring & Dis Control, Guiyang 550025, Guizhou, Peoples R China

4.Guangxi Subtrop Crops Res Inst, Nanning 530001, Peoples R China

关键词： Etoxazole; Fragment pathway; Metabolites; Ultra-performance liquid chromatography; Time-of-flight mass spectrometry

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN： 0045-6535

年卷期： 2019 年 226 卷

页码：

收录情况： SCI

摘要： Etoxazole is a newly registered and widely used acaricide. However, its metabolites were not fully understood and might exhibit similar or even higher toxicity than parent compound. Therefore, in this study, the metabolites of etoxazole in citrus, soil and earthworms were firstly identified by an ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS). Four potential metabolites in citrus, 11 in soil, and 8 in earthworms were determined. These metabolites were then further structural elucidated based on the fragment pathways, and accurate mass measurement. The distributions of etoxazole and its main metabolites (M1, M2, M3, M4 and M5) which were identified as the dehydrogenation, hydrolysis, oxidation products of etoxazole (M0) were also monitored in citrus, soil and earthworms at different exposure periods. The 45 days exposure experiment showed that M0 gradually decreased in citrus and soil samples by 80% and 28% of the initial amounts, respectively. In earthworm samples, M0 accumulated in the bodies of the worms during 24 days exposure and then decreased with time. The dissipation rate of etoxazole were citrus > earthworms > soil. Concentrations of M1 and M3 in soil were found continuously increased with time during the experimental period. Moreover, the persistence of M1 in earthworm samples was also observed. Great attention should be paid to these two compounds due to their potential risks to both environmental and human health. (C) 2019 Published by Elsevier Ltd.