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Ciprofloxacin- driven purifying selection on viral genomes accelerates soil N2O production

文献类型： 外文期刊

作者： Fang, Linfa 1 ; Lakshmanan, Prakash 3 ; Zhang, Hailin 1 ; Deng, Yue 1 ; Xiao, Ran 1 ; Wen, Teng 5 ; Ma, Bin 6 ; Ge, Tida 7 ; Mueller, Christoph 8 ; Zhang, Jinbo 5 ; Chen, Xinping 1 ; Zhu, Yongguan 12 ; Su, Xiaoxuan 1 ;

作者机构： 1.Southwest Univ, Coll Resources & Environm, Interdisciplinary Res Ctr Agr Green Dev Yangtze Ri, Chongqing 400715, Peoples R China

2.Southwest Univ, Key Lab Low Carbon Green Agr Southwestern China, Minist Agr & Rural Affairs, Chongqing 400715, Peoples R China

3.Guangxi Acad Agr Sci, Key Lab Sugarcane Biotechnol & Genet Improvement G, Guangxi Key Lab Sugarcane Genet Improvement, Sugarcane Res Inst,Minist Agr & Rural Affairs, Nanning 530007, Peoples R China

4.Univ Queensland, Crop Sci Div, Queensland Alliance Agr & Food Innovat, St Lucia, Qld 4067, Australia

5.Nanjing Normal Univ, Sch Geog, Nanjing 210023, Peoples R China

6.Zhejiang Univ, Inst Soil & Water Resources & Environm Sci, Coll Environm & Resource Sci, Hangzhou 310058, Peoples R China

7.Ningbo Univ, State Key Lab Qual & Safety Agroprod Int Sci & Tec, Ningbo 315211, Peoples R China

8.Justus Liebig Univ, Liebig Ctr Agroecol & Climate Impact Res, D-35392 Giessen, Germany

9.Justus Liebig Univ, Inst Plant Ecol, D-35392 Giessen, Germany

10.Univ Coll Dublin, Sch Biol & Environm Sci, Dublin D04 V1W8, Ireland

11.Univ Coll Dublin, Earth Inst, Dublin D04 V1W8, Ireland

12.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Beijing 100039, Peoples R China

关键词： nitrogen transformations; N2O production; soil viral community; microbial community; antibiotic pollution

期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：9.1； 五年影响因子：10.6 ）

ISSN： 0027-8424

年卷期： 2025 年 122 卷 29 期

页码：

收录情况： SCI

摘要： Viruses are ubiquitous regulators of microbial dynamics and may thus greatly influence global microbial- driven greenhouse gas emissions. Anthropogenic stressors, such as chemical contamination, are likely to amplify these viral contributions; however, their global significance and underlying mechanisms remain elusive. Utilizing 15N tracing, metagenomics, and laboratory assays, we explore soil viral communities and their evolutionary potential under the stress from antibiotic ciprofloxacin (CIP), focusing on their roles in regulating nitrogen cycling and N2O production. Through isolation and reinoculation of soil viruses, we demonstrate that CIP stimulates soil denitrification- derived N2O production, with 18 to 29% of the increase attributed to viral activity. Under CIP stress, soil viruses shift toward a lysogenic lifestyle, promoting mutualism with denitrifiers by horizontally transferring viral denitrification- related auxiliary metabolic genes (AMGs). The observed synonymous mutations in these AMGs, driven by CIP, suggest enhanced purifying selection, likely optimizing codon usage to align with host preferences. This optimization likely enhances the expression of denitrifying AMGs and increases N2O production. This study provides insights into the overlooked role of viral dynamics and genomic mutations in modulating N2O production under stressful environments, highlighting their evolutionary significance and impact on biogeochemical cycles in the Anthropocene.

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