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The Transcriptional Regulator TfmR Directly Regulates Two Pathogenic Pathways in Xanthomonas oryzae pv. oryzicola

文献类型： 外文期刊

作者： Chang, Zheng 1 ; Ma, Zengfeng 3 ; Su, Qian 1 ; Xia, Xinqi 1 ; Ye, Wenxin 1 ; Li, Ruifang 2 ; Lu, Guangtao 1 ;

作者机构： 1.Guangxi Univ, Coll Life Sci & Technol, State Key Lab Conservat & Utilizat Subtrop Agrobio, Nanning 530004, Peoples R China

2.Guangxi Acad Agr Sci, Plant Protect Res Inst, Key Lab Green Prevent & Control Fruits & Vegetable, Guangxi Key Lab Biol Crop Dis & Insect Pests,Minis, Nanning 530007, Peoples R China

3.Guangxi Acad Agr Sci, Rice Res Inst, Nanning 530007, Peoples R China

关键词： Xanthomonas; transcriptional regulator; virulence; RpfG; HrpX

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.6 ）

ISSN： 1661-6596

年卷期： 2024 年 25 卷 11 期

页码：

收录情况： SCI

摘要： Xanthomonas oryzae pv. oryzicola (Xoc) is a notorious plant pathogen. Like most bacterial pathogens, Xoc has evolved a complex regulatory network to modulate the expression of various genes related to pathogenicity. Here, we have identified TfmR, a transcriptional regulator belonging to the TetR family, as a key player in the virulence mechanisms of this phytopathogenic bacterium. We have demonstrated genetically that tfmR is involved in the hypersensitive response (HR), pathogenicity, motility and extracellular polysaccharide production of this phytopathogenic bacterium. Our investigations extended to exploring TfmR's interaction with RpfG and HrpX, two prominent virulence regulators in Xanthomonas species. We found that TfmR directly binds to the promoter region of RpfG, thereby positively regulating its expression. Notably, constitutive expression of RpfG partly reinstates the pathogenicity compromised by TfmR-deletion mutants. Furthermore, our studies revealed that TfmR also exerts direct positive regulation on the expression of the T3SS regulator HrpX. Similar to RpfG, sustained expression of HrpX partially restores the pathogenicity of TfmR-deletion mutants. These findings underscore TfmR's multifaceted role as a central regulator governing key virulence pathways in Xoc. Importantly, our research sheds light on the intricate molecular mechanisms underlying the regulation of pathogenicity in this plant pathogen.

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