Positive role of non-catalytic proteins on mitigating inhibitory effects of lignin and enhancing cellulase activity in enzymatic hydrolysis: Application, mechanism, and prospective
文献类型： 外文期刊
作者： Madadi, Meysam 1 ; Song, Guojie 1 ; Sun, Fubao 1 ; Sun, Chihe 1 ; Xia, Changlei 2 ; Zhang, Ezhen 3 ; Karimi, Keikhosro 4 ; Tu, Maobing 5 ;
作者机构： 1.Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Peoples R China
2.Nanjing Forestry Univ, Coll Mat Sci & Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Jiangsu, Peoples R China
3.Guangxi Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Nanning 530007, Peoples R China
4.Isfahan Univ Technol, Dept Chem Engn, Esfahan 8415683111, Iran
5.Univ Cincinnati, Dept Chem & Environm Engn, Cincinnati, OH 45221 USA
关键词： Lignocellulosic biomass; Enzymatic saccharification; Lignin properties; Interaction mechanisms; Non -enzymatic proteins
期刊名称：ENVIRONMENTAL RESEARCH （ 影响因子：8.431； 五年影响因子：8.399 ）
ISSN： 0013-9351
年卷期： 2022 年 215 卷
页码：
收录情况： SCI
摘要： Fermentable sugar production from lignocellulosic biomass has received considerable attention and has been dramatic progress recently. However, due to low enzymatic hydrolysis (EH) yields and rates, a high dosage of the costly enzyme is required, which is a bottleneck for commercial applications. Over the last decades, various strategies have been developed to reduce cellulase enzyme costs. The progress of the non-catalytic additive proteins in mitigating inhibition in EH is discussed in detail in this review. The low efficiency of EH is mostly due to soluble lignin compounds, insoluble lignin, and harsh thermal and mechanical conditions of the EH process. Adding non-catalytic proteins into the EH is considered a simple and efficient approach to boost hydrolysis yield. This review discussed the multiple mechanical steps involved in the EH process. The effect of physicochemical properties of modified lignin on EH and its interaction with cellulase and cellulose are identified and discussed, which include hydrogen bonding, hydrophobic, electrostatic, and cation-pi interactions, as well as physical barriers. Moreover, the effects of different conditions of EH that lead to cellulase deactivation by thermal and mechanical mechanisms are also explained. Finally, recent advances in the development, potential mechanisms, and economic feasibility of non-catalytic proteins on EH are evaluated and perspectives are presented.
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