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Marimastat alleviates oxidative stress induced cellular senescence by activating autophagy

文献类型： 外文期刊

作者： Xia, Jing 1 ; Chen, Jun 3 ; Vashisth, Manoj Kumar 1 ; Jia, Huijie 1 ; Hua, Hui 1 ; Wu, Xiao-jian 4 ; Wang, Xiao-bo 1 ;

作者机构： 1.Dali Univ, Sch Basic Med, Dali 671000, Yunnan, Peoples R China

2.Key Lab Univ Cell Biol Yunnan Prov, Dali 671000, Yunnan, Peoples R China

3.Chinese Med Hosp Shizhong, Dept Foot & Ankle Surg, Dist Leshan 12511002451599964Y, Leshan 614000, Sichuan, Peoples R China

4.Guangxi Acad Agr Sci, Microbiol Res Inst, Nanning 530007, Guangxi, Peoples R China

5.Dali Univ, Sch Basic Med, Dept Human Anat omy Histol & Embryol, Dali 671000, Yunnan, Peoples R China

关键词： Marimastat; Senescence; Oxidative stress; Autophagy; mTOR

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.322； 五年影响因子：3.498 ）

ISSN： 0006-291X

年卷期： 2022 年 620 卷

页码：

收录情况： SCI

摘要： Marimastat is one of the potent inhibitors of MMP (MMPIs) with few side effects. The impact of marimastat on cellular senescence remains unexplored. Our study evaluated the marimastate effect on oxidative stress-induced cell senescence using NIH3T3 cells. Marimastate administration was found to suppress senescence-beta-galactosidase (SA-beta-gal) activity and development linked with aging. Further-more, we observed that this effect of marimastat was closely linked with the recovery of autophagy dysfunction and mTOR suppression in H2O2-treated cells. Notably, this study demonstrated the mar-imastat effect on senescence inhibition for the first time. (C) 2022 Elsevier Inc. All rights reserved.

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