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Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network

文献类型： 外文期刊

作者： Bai, Feng 1 ; Wu, Mengbo 1 ; Huang, Wei 2 ; Xu, Weijie 1 ; Wang, Yikui 3 ; Zhang, Yang 1 ; Zhong, Zhenhui 1 ; Hong, Yiguo 4 ; Pirrello, Julien 6 ; Bouzayen, Mondher 1 ; Liu, Mingchun 1 ;

作者机构： 1.Sichuan Univ, Coll Life Sci, Key Lab Bio Resource & Eco Environm, Minist Educ, Chengdu 610065, Peoples R China

2.Minist Agr, State Key Lab Agr Genom, Key Lab Genom, BGI Res, Shenzhen 518083, Peoples R China

3.Guangxi Acad Agr Sci, Nanning 530007, Guangxi, Peoples R China

4.Univ Warwick, Sch Life Sci, Warwick CV4 7AL, England

5.Hebei Agr Univ, Coll Hort, State Key Lab North China Crop Improvement & Regul, Baoding 071000, Peoples R China

6.Univ Toulouse, Lab Rech Sci Vegetales Genomique & Biotechnol Frui, CNRS, UPS,UMR5546,Toulouse INP, Toulouse, France

期刊名称：SCIENCE ADVANCES （ 影响因子：12.5； 五年影响因子：14.1 ）

ISSN： 2375-2548

年卷期： 2025 年 11 卷 8 期

页码：

收录情况： SCI

摘要： The steroidal glycoalkaloids (SGAs) produced in Solanaceae crops, including tomato, are antinutritional because of their cellular toxicity and resultant bitter taste to humans. To make fruits palatable, SGA profiles shift from bitter and toxic alpha-tomatine to nonbitter and nontoxic esculeoside A during the ripening process. However, the mechanisms regulating this conversion remain unclear. In this study, we showed that removal of toxic and bitter SGAs is under the control of DNA demethylation, ethylene, and key transcription factors by forming a feedback loop that governs the expression of key GLYCOALKALOID METABOLISM (GAME) genes during ripening. Moreover, the ethylene-inducible transcription factors NON-RIPENING, RIPENING INHIBITOR, and FRUITFULL1 coordinately regulate the expression of GAME31, GAME40, GAME5, and the glycoalkaloid transporter gene GORKY, whereas jasmonic acid-induced MYC2 modulates the transcription of GAME36. Furthermore, DNA demethylation mediated by the DEMETER-LIKE 2 drives SGA detoxification during tomato domestication.

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