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Phenolic Fractions from Muscadine Grape "Noble" Pomace can Inhibit Breast Cancer Cell MDA-MB-231 Better than those from European Grape "Cabernet Sauvignon" and Induce S-Phase Arrest and Apoptosis

文献类型： 外文期刊

作者： Luo, Jianming 2 ; Wei, Zheng 1 ; Zhang, Shengyu 1 ; Peng, Xichun 2 ; Huang, Yu 3 ; Zhang, Yali 1 ; Lu, Jiang 3 ;

作者机构： 1.China Agr Univ, Viticulture & Enol Program, Coll Food Sci & Nutr Engn, Beijing, Peoples R China

2.Jinan Univ, Dept Food Sci & Engn, Guangzhou, Guangdong, Peoples R China

3.Guangxi Acad Agr Sci, Guangxi Crop Genet Improvement & Biotechnol Key L, Guangxi, Peoples R China

4.Shanghai Jiao Tong Univ, Sch Agr & Biol, Ctr Viticulture & Enol, Shanghai, Peoples R China

关键词： apoptosis;breast cancer cell;cell cycle;ellagic acid;muscadine grape pomace

期刊名称：JOURNAL OF FOOD SCIENCE （ 影响因子：3.167； 五年影响因子：3.376 ）

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收录情况： SCI

摘要： Tons of grape pomace which still contained a rich amount of plant polyphenols, is discarded after winemaking. Plant polyphenols have multi-functional activities for human body. In this study, polyphenols of pomaces from Muscadinia rotundifolia "Noble" and Vitis vinifera "Cabernet Sauvignon" were extracted and fractionated, and then they were analyzed with LC-MS and the inhibitory effects on breast cancer cells were compared. The inhibition on MDA-MB-231 cells of fractions from "Noble" was further evaluated. The results showed that polyphenols from 2 grape pomaces could be separated into 3 fractions, and ellagic acid and/or ellagitannins were only detected in fractions from "Noble" pomace. All 3 fractions from "Noble" pomace inhibited MDA-MB-231 better than MCF-7. But fraction 2 from "Cabernet Sauvignon" inhibited MCF-7 better while fraction 1 and fraction 3 inhibited both 2 cells similarly. Moreover, the fractions from "Noble" pomace rather than "Cabernet Sauvignon" can inhibit MDA-MB-231 better. Finally, fractions from "Noble" pomace can induce S-phase arrest and apoptosis on MDA-MB-231. These findings suggested the extracts from grape pomace especially those from "Noble", are potential to be utilized as health beneficial products or even anti-breast cancer agents.

  • 相关文献

[1]The comparative study among different fractions of muscadine grape 'Noble' pomace extracts regarding anti-oxidative activities, cell cycle arrest and apoptosis in breast cancer. Song, Shiren,Lu, Jiang,Luo, Jianming,Wei, Zheng,Zhang, Yali,Luo, Jianming,Wei, Zheng,Huang, Yu,Lu, Jiang. 2017

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